Megamind is rather sad and lonely, but he's the sad and lonely that cannot admit to it for fear of being seen as weak. So he grabs at his things and covers his workspace again.

"I don't need you to worry! You're not Minion, that's not your job! That's why I have Minion!" He will look after you, his mother had said. But he's not here now. Megamind really needs him here now, but--

Well, sometimes the Rolling Stones were wrong. Sometimes you didn't get what you want-- sometimes you didn't even get what you need.